Publications

Felder RA, Gildea JJ, Xu P, Yue W, Armando I, Carey RM, Jose PA.
Inverse Salt Sensitivity of Blood Pressure: Mechanisms and Potential Relevance for Prevention of Cardiovascular Disease.
Curr Hypertens Rep. 2022 Jun 16. doi: 10.1007/s11906-022-01201-9.

Yang J, Hall JE, Jose PA, Chen K, Zeng C.
Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.
Pharmacol Ther. 2022 Apr 27;239:108194. doi: 10.1016/j.pharmthera.2022.108194.

Jiang X, Liu Y, Zhang XY, Liu X, Liu X, Wu X, Jose PA, Duan S, Xu FJ, Yang Z.
Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway. Hypertension.
2022 Jun 8:101161HYPERTENSIONAHA12118791. doi: 10.1161/HYPERTENSIONAHA.121.18791

Huang J, Tiu AC, Jose PA, Yang J.
Sorting nexins: role in the regulation of blood pressure.
FEBS J. 2021 Nov 30:10.1111/febs.16305. doi: 10.1111/febs.16305.

Luo H, Lan C, Fan C, Gong X, Chen C, Yu C, Wang J, Luo X, Hu C, Jose PA, Xu Z, Zeng C.
Downregulation of AMPK/PPARδ Signaling promotes endoplasmic reticulum stress-induced endothelial dysfunction in adult rat offspring exposed to maternal diabetes.
Cardiovasc Res. 2021 Aug 20:cvab280. doi: 10.1093/cvr/cvab280.

Fan C, Asico LD, Villar VAM, Hunt J, Cuevas S, Armando I, Jose PA, Konkalmatt PR.
NFAT5 Is Involved in GRP-Enhanced Secretion of GLP-1 by Sodium.
Int J Mol Sci. 2021 Apr 12;22(8):3951. doi: 10.3390/ijms22083951.

Jiang X, Shao M, Liu X, Liu X, Zhang X, Wang Y, Yin K, Wang S, Hu Y, Jose PA, Zhou Z, Xu FJ, Yang Z.
Reversible Treatment of Pressure Overload-Induced Left Ventricular Hypertrophy through Drd5 Nucleic Acid Delivery Mediated by Functional Polyaminoglycoside.
Adv Sci (Weinh). 2021 Jan 6;8(5):2003706. doi: 10.1002/advs.202003706.

Lan C, Cao N, Chen C, Qu S, Fan C, Luo H, Zeng A, Yu C, Xue Y, Ren H, Li L, Wang H, Jose PA, Xu Z, Zeng C.
Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair.
Cell Prolif. 2020 Nov;53(11):e12910. doi: 10.1111/cpr.12910.

De Miguel C, Kraus AC, Saludes MA, Konkalmatt P, Ruiz Domínguez A, Asico LD, Latham PS, Offen D, Jose PA, Cuevas S.
ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction.
Int J Mol Sci. 2020 Sep 24;21(19):7048. doi: 10.3390/ijms21197048.

Tiu AC, Yang J, Asico LD, Konkalmatt P, Zheng X, Cuevas S, Wang X, Lee H, Mazhar M, Felder RA, Jose PA, Villar VAM.
Lipid rafts are required for effective renal D1 dopamine receptor function.
FASEB J. 2020 May;34(5):6999-7017. doi: 10.1096/fj.201902710RR.

Xu P, Gildea JJ, Zhang C, Konkalmatt P, Cuevas S, Bigler Wang D, Tran HT, Jose PA, Felder RA.
Stomach gastrin is regulated by sodium via PPAR-α and dopamine D1 receptor.
J Mol Endocrinol. 2020 Feb;64(2):53-65. doi: 10.1530/JME-19-0053.

Han F, Konkalmatt P, Mokashi C, Kumar M, Zhang Y, Ko A, Farino ZJ, Asico LD, Xu G, Gildea J, Zheng X, Felder RA, Lee REC, Jose PA, Freyberg Z, Armando I.
Dopamine D2 receptor modulates Wnt expression and control of cell proliferation.
Sci Rep. 2019 Nov 14;9(1):16861. doi: 10.1038/s41598-019-52528-4.

Gildea JJ, Xu P, Kemp BA, Carey RM, Jose PA, Felder RA.
The Dopamine D1 Receptor and Angiotensin II Type-2 Receptor are Required for Inhibition of Sodium Transport Through a Protein Phosphatase 2A Pathway.
Hypertension. 2019 Jun;73(6):1258-1265. doi: 10.1161/HYPERTENSIONAHA.119.12705.

Yang J, Villar VAM, Rozyyev S, Jose PA, Zeng C.
The emerging role of sorting nexins in cardiovascular diseases.
Clin Sci (Lond). 2019 Mar 15;133(5):723-737. doi: 10.1042/CS20190034.

Cuevas S, Villar VAM, Jose PA.
Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation.
Pharmacogenomics J. 2019 Aug;19(4):315-336. doi: 10.1038/s41397-019-0082-4.

Amosco MD, Tavera GR, Villar VAM, Naniong JMA, David-Bustamante LMG, Williams SM, Jose PA, Palmes-Saloma CP.  
Non-additive effects of ACVR2A in preeclampsia in a Philippine population.
BMC Pregnancy Childbirth. 2019 Jan 8;19(1):11. doi: 10.1186/s12884-018-2152-z.

Wu G, Jose PA, Zeng C.
Noncoding RNAs in the Regulatory Network of Hypertension.
Hypertension. 2018 Nov;72(5):1047-1059. doi: 10.1161/HYPERTENSIONAHA.118.11126.

Yang X, Yue R, Zhang J, Zhang X, Liu Y, Chen C, Wang X, Luo H, Wang WE, Chen X, Wang HJ, Jose PA, Wang H, Zeng C.
Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways.
J Am Heart Assoc. 2018 Jul 12;7(14):e005171. doi: 10.1161/JAHA.116.005171.

Tiu AC, Bishop MD, Asico LD, Jose PA, Villar VAM.
Primary Pediatric Hypertension: Current Understanding and Emerging Concepts.
Curr Hypertens Rep. 2017 Sep;19(9):70. doi: 10.1007/s11906-017-0768-4.

Yang J, Jose PA, Zeng C.
Gastrointestinal-Renal Axis: Role in the Regulation of Blood Pressure.
J Am Heart Assoc. 2017 Mar 6;6(3):e005536. doi: 10.1161/JAHA.117.005536.

Diao Z, Asico LD, Villar VAM, Zheng X, Cuevas S, Armando I, Jose PA, Wang X.
Increased renal oxidative stress in salt-sensitive human GRK4γ486V transgenic mice.
Free Radic Biol Med. 2017 May;106:80-90. doi: 10.1016/j.freeradbiomed.2017.02.021.

Fan Y, Zhang J, Chen CY, Xiao YB, Asico LD, Jose PA, Xu JC, Qian GS, Zeng CY.
Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis.
Cardiovasc Res. 2017 Apr 1;113(5):519-530. doi: 10.1093/cvr/cvx025.

Yang J, Villar VA, Armando I, Jose PA, Zeng C.
G protein-coupled receptor kinases: crucial regulators of blood pressure.
J Am Heart Assoc. 2016 Jul 7;5(7). pii: e003519. 

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Jose PA, Felder RA, Yang Z, Zeng C, Eisner GM.
Gastrorenal axis.
Hypertension. 2016 Jun;67(6):1056. 

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Sanada H, Yoneda M, Yatabe J, Williams SM, Bartlett J, White MJ, Gordon LN, Felder RA, Eisner GM, Armando I, Jose PA.
Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.
Pharmacogenomics J. 2016 Feb;16(1):3-9. 

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Wang Z, Zeng C, Villar VA, Chen SY, Konkalmatt P, Wang X, Asico LD, Jones JE, Yang Y, Sanada H, Felder RA, Eisner GM, Weir MR, Armando I, Jose PA.
Human GRK4γ142V variant promotes angiotensin II type I receptor-mediated hypertension via renal histone deacetylase type 1 inhibition.
Hypertension. 2016 Feb;67(2):325-34. 

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Cuevas S, Yang Y, Konkalmatt P, Asico LD, Feranil J, Jones J, Villar VA, Armando I, Jose PA.
Role of nuclear factor erythroid 2-related factor 2 in the oxidative stress-dependent hypertension associated with the depletion of DJ-1. 
Hypertension. 2015 Jun;65(6):1251-7.

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Yu P, Sun M, Villar VA, Zhang Y, Weinman EJ, Felder RA, Jose PA.
Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.
Cell Signal. 2014 Nov;26(11):2521-9.

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Chen Y, Asico LD, Zheng S, Villar VA, He D, Zhou L, Zeng C, Jose PA.
Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis.
Hypertension. 2013 Nov;62(5):927-33.

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Zeng C, Asico LD, Yu C, Villar VA, Shi W, Luo Y, Wang Z, He D, Liu Y, Huang L, Yang C, Wang X, Hopfer U, Eisner GM, Jose PA.
Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions.
Kidney Int. 2008 Sep;74(6):750-9.

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Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, Moore JH, Ritchie MD, Williams SM, Pezzullo JC, Sasaki M, Eisner GM, Jose PA, Felder RA.
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.
Clin Chem. 2006 Mar;52(3):352-60.

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Zeng C, Yang Z, Wang Z, Jones J, Wang X, Altea J, Mangrum AJ, Hopfer U, Sibley DR, Eisner GM, Felder RA, Jose PA.
Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells.
Hypertension. 2005 Apr;45(4):804-10.

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Williams SM, Ritchie MD, Phillips JA 3rd, Dawson E, Prince M, Dzhura E, Willis A, Semenya A, Summar M, White BC, Addy JH, Kpodonu J, Wong LJ, Felder RA, Jose PA, Moore JH.
Multilocus analysis of hypertension: a hierarchical approach.
Hum Hered. 2004;57(1):28-38.

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Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams SM, Gainer J, Brown NJ, Hazen-Martin D, Wong LJ, Robillard JE, Carey RM, Eisner GM, Jose PA.
G protein-coupled receptor kinase 4 gene variants in human essential hypertension.
Proc Natl Acad Sci USA 2002 Mar 19;99(6):3872-7.

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Asico LD, Ladines C, Fuchs S, Accili D, Carey RM, Semeraro C, Pocchiari F, Felder RA, Eisner GM, Jose PA.
Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.
J Clin Invest. 1998 Aug 1;102(3):493-8.

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Albrecht FE, Drago J, Felder RA, Printz MP, Eisner GM, Robillard JE, Sibley DR, Westphal HJ, Jose PA.
Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension.
J Clin Invest. 1996 May 15;97(10):2283-8.

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Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Grinberg A, Lee EJ, Huang SP, Bartlett PF, Jose PA, Sibley DR, Westphal H.
Altered striatal function in a mutant mouse lacking D1A dopamine receptors.
Proc Natl Acad Sci USA. 1994 Dec 20;91(26):12564-8.

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