Our laboratory tests the efficacy of newly developed drugs and nutrichemicals to treat hypertension in mice that are genetically altered to either not express endogenous murine genes (knockouts) or express human genes (knockins, transgenics) that regulate blood pressure.
R01DK039308, Renal dopamine-1 receptor defect in hypertension. The major goal of this project is to determine how the gastro-renal reflex regulates sodium balance and blood pressure. This grant has been funded by the National Institutes of Health for 30 years.
R01DK119652 (Lipid rafts, dopamine 1 receptor and hypertension). The major goal of this project is to determine the role of SNX19 in promoting normal D1R function, by trafficking D1R to lipid rafts in renal tubule plasma membrane).